THE EFFECT OF ETHANOLIC EXTRACT OF MISWAK STEMS (SALVADORA PERSICA ) ON THE HEALING OF POST-EXTRACTION SOCKETS IN WISTAR RATS (RATTUS NORVEGICUS)

Abstract

The high prevalence of post-extraction complications, such as delayed wound healing and suboptimal bone regeneration, underscores the importance of effective therapeutic interventions. This study evaluated the efficacy of ethanolic extract of Miswak stems (Salvadora persica ) in accelerating post-extraction socket healing in Wistar rats. The study involved two groups: the intervention group treated with 50% S. persica extract and the control group treated with distilled water. Each group consisted of 16 samples, with clinical and histopathological evaluations conducted on the fifth-day post-extraction. The methodology included topical application of S. persica extract on extraction sockets under controlled laboratory conditions, followed by clinical assessments using the Inflammatory-Proliferative-Remodeling (IPR) scoring system and histopathological analysis of osteoblast density. Results showed significantly improved clinical healing scores (mean IPR: 7 vs. 6 in the control group) and higher osteoblast density in the intervention group, indicating accelerated bone remodeling and tissue repair. Statistical analysis (Mann-Whitney and paired sample t-test) confirmed the effectiveness of the extract (p < 0.05). These findings suggest that S. persica extract effectively enhances oral wound healing and bone regeneration, likely due to its bioactive compounds with anti-inflammatory and osteogenic properties. Further studies are required to evaluate its safety and long-term efficacy for clinical applications.